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Luteolin Usage and Synthesis

The natural flavonoids Luteolin is a very representative natural flavonoids. It is a weakly acidic tetrahydroxyflavonoids. It is widely distributed in the plant kingdom. It is mainly found in honeysuckle, chrysanthemum, nepeta, Prunella vulgaris and other medicines. Medium, thyme, brussels sprouts, cabbage, cauliflower, beets, broccoli, carrots and other vegetables, and are distributed in the form of glycosides in celery, green peppers, perilla leaves and legumes (Arachis hypogaea) fruit shells, white hair summer Blight (Ajuga decumbus), Lonicera japonica Thunb (Lonicera japonica Thunb), Gentianopsis paludosa (Gentianopsis paludosa), black water valerian (Valeriana amurensis Smir) and many other plants. The pure product of luteolin is yellow crystalline powder.


Solubility Luteolin is isolated from ethanol as golden needles containing a crystal water. It is soluble in ethanol; slightly soluble in hot water, but hardly soluble in cold water. The aqueous solution is pleasing to the eye, and it is soluble in 10% sodium hydroxide aqueous solution and is dark yellow. Stable under normal conditions.


Extraction methods The literature reports that the methods for extracting luteolin, the effective component of peanut shells, include solvent method, ultrasonic method, microwave method and supercritical CO 2 method, etc. Among them, solvent extraction methods are mostly reported. Solvent extraction methods mostly use methanol, acetone and ethyl acetate. Ester is the extraction solvent.


Pharmacological activity 1. Luteolin has a variety of pharmacological activities. Plants rich in luteolin are often used as Chinese medicine to treat diseases. With the deepening of research on luteolin, it has been found that it has anti-tumor effects such as inhibiting tumor cell proliferation, inducing tumor cell apoptosis and sensitizing the activity of anti-cancer drugs, but also has anti-inflammatory, anti-oxidant and protection of the nervous system, etc. effect.


2. Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor 2 and interleukin 6 inhibitor 3. It can significantly reverse the xylazine/chlorine-induced anesthesia in mice. 4 Preclinical studies have shown that luteolin may have pharmacological effects, including antioxidant, anti-inflammatory, antibacterial and anti-cancer. Preliminary studies have found that luteolin can inhibit angiogenesis and induce cell apoptosis, affect the development of animal model tumors, reduce the growth rate of tumors, and increase the cytotoxicity of certain anticancer drugs to tumor cells. This indicates that luteolin may be Potential cancer chemopreventive drugs and chemotherapy drugs.


3. The mechanism of the biological activity of luteolin may be regulating the level of ROS, inhibiting topoisomerase I and topoisomerase II, reducing the activity of NF-κB and AP-1 transcription factors, stabilizing p53 and inhibiting phosphoinositol 3 -Activity of kinase, signal transducer and activator of transcription 3 (STAT3), insulin-like growth factor 1 receptor (IGF1R) and human epidermal growth factor receptor II.

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